Figure 2: Phylogenetic tree of endogenous retroviruses based on reverse transcriptase protein sequences.

Foamy virus (FV) sequences (light-blue shading) form two distinct phylogenetic groups, one tetrapod specific and one teleost specific. Both groups contain endogenous foamy virus (EFV) sequences (the ewly identified platyfish and cod sequences are highlighted by dark-blue shading). Alignment was carried out with ClustalW (223 amino acids), and the phylogenetic tree was constructed with the PhyML package using maximum-likelihood methods38 with default bootstrap (shown at the beginning of branches) and optimized calculation options. FV, foamy virus; MuERV-L, Mus musculus endogenous retrovirus-L; BAEV, baboon endogenous virus; FENV1, feline endogenous virus 1; EFV, endogenous foamy virus, MLV, murine leukemia virus; HERV-K, human endogenous retrovirus-K; MMTV, mouse mammary tumor virus; HIV-1, human immunodeficiency virus-1. The scale bar represents the number of substitutions per site.