Figure 2: Molecular functions enriched among N. americanus genes, stage-enriched genes and the N. americanus degradome.

(a) 'Molecular function' gene ontology terms enriched in specific life-cycle stages and in N. americanus compared to other species. Included are (i) categories enriched in the iL3 or adult life cycle stages in N. americanus, (ii) categories significantly (P ≤ 1 × 10−5) over-represented or depleted in N. americanus compared to at least two of the comparison species, and (iii) second-order root nodes. TF, transcription factor. (b,c) Expression profiling of N. americanus proteases with C. elegans orthologs (b) or with no C. elegans orthologs (c).