Supplementary Figure 7: Cyst cell death does not contribute to selection against mutant mitochondrial genomes in the germarium of heteroplasmic flies. | Nature Genetics

Supplementary Figure 7: Cyst cell death does not contribute to selection against mutant mitochondrial genomes in the germarium of heteroplasmic flies.

From: Selective propagation of functional mitochondrial DNA during oogenesis restricts the transmission of a deleterious mitochondrial variant

Supplementary Figure 7

(a) Terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL; green) of germaria from wild-type and heteroplasmic mt:CoIT300I ovaries at 18 °C or 29 °C and counterstained with DAPI (pseudocolored with red for better illustration) to label nuclei. Arrowheads, TUNEL-positive nuclei. Scale bars, 10 μm. (b) Quantification of the number of TUNEL-positive nuclei per germarium at 18 °C (wild-type n = 9, mt:CoIT300In = 8) or 29 °C (wild-type n = 14, mt:CoIT300I n = 15). Value, mean ± s.d.

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