Supplementary Figure 2: Quantile-quantile plots for single-variant analysis results of lipid traits | Nature Genetics

Supplementary Figure 2: Quantile-quantile plots for single-variant analysis results of lipid traits

From: Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

Supplementary Figure 2

Quantile-quantile plots (QQ) for single variant association analysis results for lipid traits in Stage 1 samples (N=5,643). We display separate Q-Q curves for previously known GWAS variants as published by the Global Lipid Genetic Consortium1 (red), variants within 500kb from a GWAS variant (blue), and association for other coding variants >500kb away from lead GWAS SNPs (black). 95% confidence intervals for the null hypothesis of no association are shown in grey. HDL, high-density lipoprotein; LDL, low-density lipoprotein. Genomic control lambda values were: HDL λGC = 1.06; LDL λGC = 1.04; TC λGC = 1.08; TG λGC = 1.04.

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