Supplementary Figure 7: Adenovirus-mediated TM6SF2 overexpression and knockdown does not elevate alanine aminotransferase | Nature Genetics

Supplementary Figure 7: Adenovirus-mediated TM6SF2 overexpression and knockdown does not elevate alanine aminotransferase

From: Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

Supplementary Figure 7

This figure shows no significant differences in ALT levels in experimental vs. control mice after either overexpression or knockdown of Tm6sf2. ALT activity in mice was determined in serum collected from overnight-fasted wild-type mice and experimental mice including Ad-LacZ, Ad-TM6SF2, Ad-shLacZ and Ad-shTM6SF2 mice. No significant differences were observed between any experimental group and the control group (no adenovirus injection). 25 animals were analyzed, 5 in each study group.

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