Supplementary Figure 4: DIPG patients with ALT phenotype have longer telomeres and are diagnosed at an older age. | Nature Genetics

Supplementary Figure 4: DIPG patients with ALT phenotype have longer telomeres and are diagnosed at an older age.

From: Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations

Supplementary Figure 4

All ALT-positive DIPG patients were found in the H3-K27M subgroup. By WGS, these patients had significantly longer telomeres; (a) 2.28 times longer than their matched normal vs. non-ALT DIPG patients who had telomeres that were 1.47 times shorter than their matched normal (P < 0.0001). (b) There was a significant difference in age of diagnosis between ALT-negative (5.89 ± 2.82 years) vs. ALT-positive (10.08 ± 3.61 years) patients; P <0.0001). Error bars represent s.e.m.

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