Supplementary Figure 4: Principal-component analysis showing that the melanoma cases and UK10K controls are ancestry matched.
From: POT1 loss-of-function variants predispose to familial melanoma
Plot showing the first and second principal components (PC1 and PC2, respectively). Ancestry was estimated using the 1000 Genomes Project individuals1 and then projected onto the melanoma (gray) and UK10K control (orange) cohorts. Note that controls lying greater than 2 s.d. from the mean PC1 or PC2 scores, calculated using only European individuals in the 1000 Genomes Project data set, are not shown in this plot and were not considered in subsequent analyses. We did not depict three individuals from the QFMP cohort for whom we could not determine the zygosity of the called genotypes.
