Supplementary Figure 3: Alignment of the regions flanking the six missense variants in orthologous proteins, showing the conservation of the altered amino acids.
From: De novo mutations in HCN1 cause early infantile epileptic encephalopathy
Multiple pairwise alignments were performed using ClustalW 2.1 (http://www.genome.jp/tools/clustalw/). The amino acids altered by the mutations are highlighted. Full alignments including all species are provided as a Supplementary Note.
