Supplementary Figure 2: Differential allelic expression of ALDH1A2 transcript in cartilage according to genotype at rs3204689. | Nature Genetics

Supplementary Figure 2: Differential allelic expression of ALDH1A2 transcript in cartilage according to genotype at rs3204689.

From: Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31

Supplementary Figure 2

Allelic imbalance depicted by allele ratios (G/C) plotted as log2 values for 22 individuals heterozygous for the rs3204689 SNP. Cartilage was isolated from the hip or knee joints of individuals with osteoarthritis. (a) Preserved (macroscopically normal) articular cartilage samples (N = 15). (b) Osteoarthritis-affected articular cartilage samples (N = 17). *P < 0.0005, **P < 0.0001, ***P < 0.00001.

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