Supplementary Figure 14: Validation of the result that men with LOY are at a higher risk for all-cause mortality in an independent cohort (PIVUS).

Panel a shows the results from Cox proportional hazards regression models with all-cause mortality as the endpoint using different thresholds in the analyses of 488 men. The participants were classified into groups 1 and 0 on the basis of their degree of LOY using different thresholds for mLRR-Y, i.e., the median LRR in the male-specific part of chromosome Y. The number of participants (n) with LOY and the minimum percentage of affected cells for each subject are given for each of the tested thresholds. On the basis of these results, mLRR-Y at –0.5 is the most informative threshold for survival analyses in the PIVUS cohort. Panel b shows the results from a Cox proportional hazards regression model testing the effect of LOY on risk for all-cause mortality in 488 PIVUS men at the –0.5 threshold. The survival of men with LOY is represented by the red curve. HRs, P value, 95% CIs and the number of events are shown.