Supplementary Figure 1: Conserved organization of the 8q24 region in mice and humans.

Representation of the 8q24 interval (hg19, chr. 8: 127,200,000–131,500,000) from the UCSC Genome Browser⁶⁴ with the 640-kb CL/P risk interval boxed³. ENCODE tracks summarizing regulatory and transcription activities (from seven cell lines) are shown⁶⁵, as well as the score of evolutionary conservation of the sequence (GERP track⁶⁶). The paucity of gene annotation, transcriptional activity (RNA-seq tracks) and promoter-associated chromatin marks (H3K4me3) highlights the 'gene desert' constituted by this region between PVT1 and GSDMC. The region comprises, however, many evolutionarily conserved elements (peaks in the GERP track) and potential tissue-specific enhancers (peaks in the H3K4me1 and H3K27ac tracks). The Mouse Net track shows the extensive syntenic chain linking mouse and human orthologous sequences, with extreme conservation in sequence and relative order between the two species.