Supplementary Figure 5: Cardiovascular disease and hypertension metabolic subnetwork.
From: An atlas of genetic influences on human blood metabolites
Network data were annotated with expert knowledge to illustrate correlations between molecular relationships and knowledge on blood pressure regulation, blood coagulation and known molecular risk factors for cardiovascular disease and hypertension. Black nodes and edges represent a subnetwork from the metabolite network in Figure 2. This subnetwork contains metabolites (circular nodes) and genes (diamond-shaped nodes) of the fibrinogen cleavage (left) and kininogen/kinin (right) systems and their interconnections as derived from our data. Gray nodes and edges, annotations of biochemical function based on expert knowledge27; colored nodes and edges, reported associations based on genome-wide studies for blood pressure regulation (orange), blood coagulation (blue) and cholesterol levels (purple; information in Supplementary Table 6).
