Supplementary Figure 4: Interaction between NAT8 and PYROXD2 variants.

(a) Box plots of PYROXD2 and NAT8 transcript levels in fat, skin and LCLs as a function of the genotype conformation between the two variants rs10469966 (NAT8) and rs4488133 (PYROXD2). (b) Summary of association and interaction effects at the two loci, summarizing association statistics and variances explained under the single-SNP, additive and interaction models. An ANOVA F test was used to test the significance of the interactive model over the additive model. The association test with X-12093 reported here is based on a combined TwinsUK and KORA data set; all other analyses were carried out using unrelated TwinsUK singletons. See also Figure 4.