Supplementary Figure 3: Pathway enrichment analysis.
From: Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma
(a) Gene ontology analysis shows that the SNS expression profile is enriched in genes involved in several developmental processes, including skeletal system morphogenesis and general organ development (minimum P = 3.39 × 10–14 for skeletal system morphogenesis, false discovery rate (FDR) = 1.37 × 10–10; maximum P = 1.14 × 10–10 for organ morphogenesis, FDR = 4.64 × 10–8). (b) Enrichment process network analysis shows that SNS exhibits differential expression of several biological circuits involved in neural, cardiac, bone and other developmental processes (minimum P = 4.19 × 10–4 for neural development, FDR = 0.058; maximum P = 0.031 for olfactory transduction, FDR = 0.427). Enrichment analyses were performed using the MetaCore gene regulatory network database in order to identify networks that are significantly enriched by differentially expressed genes. Modified gene ontology terms are based on the GO database (http://www.geneontology.org/).
