Supplementary Figure 5: ENCODE data for the TANC1 locus.

(a) TANC1 coding region. (b) Expanded view of the LD block containing all the associated variants. (c) Expanded view of the site where the responsible SNPs are located, after conditional analyses, of all the identified effect in the RADIOGEN cohort (rs264663). The UCSC Gene annotation track is a set of gene predictions based on data from RefSeq, GenBank, CCDS, Rfam and the tRNA Genes track. (Data last updated 14 June 2013.) The Chromatin State Segmentation track displays a chromatin state segmentation for each of nine human cell types.. The H3K4me3 track shows the levels of enrichment of the H3K4me3 histone mark across the genome as determined by a ChIP-seq assay. The H3K4me3 histone mark is the trimethylation of lysine 4 of the H3 histone protein, and it is associated with promoters that are active or poised to be activated. The H3K4me1 track shows the levels of enrichment of the H3K4me1 histone mark across the genome as determined by a ChIP-seq assay. The H3K4me1 histone mark is the monomethylation of lysine 4 of the H3 histone protein, and it is associated with enhancers and with DNA regions downstream of transcription start sites. The H3K27ac track shows the levels of enrichment of the H3K27ac histone mark across the genome as determined by a ChIP-seq assay. The H3K27ac histone mark is the acetylation of lysine 27 of the H3 histone protein, and it is thought to enhance transcription, possibly by blocking the spread of the repressive histone mark H3K27me3. The DNase clusters track shows DNase hypersensitive areas. Tnx Factor track shows regions where transcription factors, proteins responsible for modulating gene transcription, bind to DNA, as assayed by ChIP-seq.