Supplementary Figure 3: Residual association at 5q22 after adjusting for rs1438672. | Nature Genetics

Supplementary Figure 3: Residual association at 5q22 after adjusting for rs1438672.

From: Genome-wide association analysis of eosinophilic esophagitis provides insight into the tissue specificity of this allergic disease

Supplementary Figure 3

After adjusting for any of the most highly associated variants in the region (rs1438672), a group of 12 variants between TSLP and WDR36 demonstrate residual association (0.001 < P < 0.05). After accounting for multiple testing, we cannot reject the null hypothesis that there is one independent genetic effect in the region. P values (–log10) for the genetic association analysis are plotted as a function of the genomic positions of each imputed variant (minor allele frequency (MAF) > 0.01) on chromosome 5 (Chr5) using a logistic regression model adjusting for the genotype of rs1438672. Genes in the region are shown below. The blue lines indicate the recombination rates in cM per Mb using HapMap controls.

Back to article page