Supplementary Figure 7: Analysis of clinical covariates with molecular subtypes.
From: Multi-tiered genomic analysis of head and neck cancer ties TP53 mutation to 3p loss
(a) Hazard ratios (x axis) for each component (y axis) of a multivariate Cox model of patient survival, including the TP53-3p event and clinical variables. All hazard ratios are relative to the absence of the clinical or molecular event. Stepwise feature selection was performed to reduce the model to informative clinical variables only. See Supplementary Table 1 for more information on clinical variables. (b–d) Re-creation of the main prognostic associations from this study in a clinically homogenous cohort of 175 patients with a history of smoking who were under 75 years of age.
