Supplementary Figure 8: JAGN1-mutated human neutrophils exhibit aberrant glycosylation.
From: JAGN1 deficiency causes aberrant myeloid cell homeostasis and congenital neutropenia
MALDI-TOF mass spectrometry of permethylated N-glycans from JAGN1-mutated neutrophils from (a) patient P8 and (b) patient P7. Other conditions are identical to those in Supplementary Figure 6. The N-glycans of the JAGN1-mutated human neutrophils are characterized by decreased abundance or almost a complete absence of the tri- and tetra-antennary core-fucosylated structures containing double and triple antenna-fucosylated residues.
