Supplementary Figure 4: Comparative glycoproteomic profiles of bone marrow neutrophils and peritoneal neutrophils recruited after Candida albicans challenge.
From: Jagunal homolog 1 is a critical regulator of neutrophil function in fungal host defense
Comparative glycoproteomic profiles of neutrophils isolated from (a) the bone marrow of Jagn1Δhem and Jagn1fl/fl mice or (b) the peritoneum of Jagn1Δhem and Jagn1fl/fl mice 24 h after intraperitoneal Candida albicans challenge. The plot depicts the median ratios for all glycopeptides found to bear the indicated N-glycan structures in Jagn1Δhem versus Jagn1fl/fl neutrophils. Ratios below 1 indicate downregulation in knockout neutrophils, and ratios above 1 indicate upregulation in Jagn1Δhem knockout cells. Sugar structures shown in Figure 2a are highlighted in bold. In all panels, data are shown as box-and-whisker plots. Horizontal bars indicate the median; boxes span the respective interquantile range; whiskers extend to 1.5 times the interquantile range; and outliers are indicated by circles. n = 3 samples isolated from 3 different mice for each genotype.
