Supplementary Figure 6: LD block analysis of the disease-associated SNPs in the ABCA1 gene and their relationship with previously described markers also mapping to ABCA1 showing association with HDL and CAD.
From: Common variants near ABCA1 and in PMM2 are associated with primary open-angle glaucoma
LD block analysis was performed using CHB genotyping data from the dbSNP database. Previous studies indicated that rs4149274 in intron 5 of the ABCA1 gene was significantly associated with HDL and CAD, and rs4149274 and rs1883025 in intron 2 of the ABCA1 gene were shown to be significantly associated with AMD. rs2164560, rs2472459 and rs2472519 are associated with POAG in this study. Values for r2 (left) and D′ (right) are shown in the block.
