Supplementary Figure 1: Quantile-quantile plot in the discovery cohort.

This figure shows the Q-Q plot created in R for two-sided P-values obtained from the association analysis of the genome-wide SNPs (using logistic regression with sex and the first 6 principal components fitted as covariates) with the development of primary open-angle glaucoma (POAG). The x-axis shows the expected distribution of -log₁₀(P-values) under the null hypothesis of no association. The y-axis show the observed -log₁₀(P-values) in the association analysis in the discovery cohort in this study (1,155 advanced POAG cases and 1,992 controls). The P-values were corrected for the genomic inflation factor lambda (λ = 1.06 for imputed SNPs). The curves are made of dots each being an observed -log₁₀(P-values) calculated for one or more SNPs. The red indicator lines show where x = y.