Supplementary Figure 4: Maximum-parsimonious phylogeny of 23 P. aeruginosa isolates of the DK12 clone type.
From: Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis
The phylogeny has a consistency of 0.95 and is based on 576 SNPs identified from whole-genome comparison of the isolates. Branch lengths are drawn to scale, and the scale bar indicates the number of SNPs that have accumulated over the branch. Alleles of P. aeruginosa reference strain PAO1 were used to determine the MRCA. The overall transition-to-transversion ratio was 3.6 (452 transitions, 125 transversions), but a mutational skew towards transition substitutions (88 transitions, 3 transversions) was observed in the branch leading to hypermutable isolate 104, which carries a 24-bp deletion in the DNA mismatch repair gene mutL.
