Supplementary Figure 6: CRCs that overexpress RSPO1, RSPO2 or RSPO3 and lack APC mutations have decreased expression or an increased number of mutations in SMAD4. | Nature Genetics

Supplementary Figure 6: CRCs that overexpress RSPO1, RSPO2 or RSPO3 and lack APC mutations have decreased expression or an increased number of mutations in SMAD4.

From: Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression

Supplementary Figure 6

(a) Five CRC cases (highlighted by asterisks) out of seven CRC cases, which showed RSPO1 or RSPO2 overexpression but carried no mutations in APC, had decreased SMAD4 expression and/or mutations in SMAD4 (ref. 4). (b) Six of seven CRC cases, which showed RSPO2 or RSPO3 overexpression but carried no APC mutations, showed deregulation of SMAD4 (modified from Supplementary Figure 21 in ref. 5).

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