Supplementary Figure 5: Clonal evolution of MDS in the context of germline ETV6 mutation.
From: Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy
Analysis of germline and serial bone marrow samples in family A III-2. Electropherograms from Sanger sequencing of BCOR, RUNX1, and KRAS mutations in genomic DNA derived from (a) marrow fibroblasts, (b) bone marrow mononuclear cells at age 17 when the patient had refractory cytopenias with multilineage dysplasia (RCMD) and (c) bone marrow mononuclear cells at age 21 when the patient’s disease progressed to refractory anemia with excess blasts type 1 (RAEB-1).
