Supplementary Figure 10: Mutation burden in sporadic colorectal and endometrial cancers.

(a) The total number of somatic mutations in sporadic colorectal and endometrial cancers with either MMR mutations, POLE mutations or both. (b) The relationship between mutation burden and copy number. Colon cancers are plotted on the top row, and endometrial cancers are plotted on the bottom row. In all panels, each dot represents one tumor specimen. The red dots represent the genotype of interest. That is, on the left, red dots are samples with mutation in an MMR gene but not in POLE; in the middle, red dots represent POLE-mutated samples, without MMR mutations; and, on the right, red dots represent samples with both MMR and POLE mutations, which contain the highest number of point mutations and fewest copy number alterations. Data are from http://www.cbioportal.org/.