Supplementary Figure 12: Sequencing coverage.

(a) Coverage of exome sequencing data. Shown is a box plot with each tumor's coverage, for all bases in the exome target. The red dotted line shows the minimum coverage of 25× required for downstream analysis. (b) Coverage of genome sequence data. Shown is the average coverage for all tumor genomes sequenced. The red dotted line shows the minimum desired coverage of 30×.