Supplementary Figure 4: Additive expression of Mad1l1.
Mad1l1 (mitotic arrest deficient 1–like 1) is one of several thousand genes identified with statistically significant allelic imbalance. (a) For each animal, two points are plotted to reflect the proportion of allele-specific Mad1l1 reads aligned to each parent (colored by genotype). The F1 allele-specific data indicate that, at the cis level, the PWK/PhJ Mad1l1 allele is stronger than the WSB/EiJ allele, which is stronger than the CAST/EiJ allele. (b) For each animal, one point is plotted to reflect the total number of reads aligned to Mad1l1, regardless of whether they are allele specific or not. The points for F1 mice are colored with the maternal strain on the outside and the paternal strain on the inside. This pattern indicates that the cis effect identified in the top panel is consistent with total expression in the parental strains. Furthermore, the expression levels in the F1 samples are intermediate to those of their parents, indicating an additive effect.
