Supplementary Figure 5: Overdominant expression of Fos. | Nature Genetics

Supplementary Figure 5: Overdominant expression of Fos.

From: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

Supplementary Figure 5

Fos (FBJ osteosarcoma oncogene) overdominance effect. (a) The F1 allele-specific data indicate that, at the cis level, the PWK/PhJ allele is stronger than the WSB/EiJ allele, which is stronger than the CAST/EiJ allele. (b) This cis effect is consistent with total expression in the parental strains, but the expression levels in the F1 animals show a dominance effect. (c) The dominance effect replicated in the brain microarray data.

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