Supplementary Figure 2: Joint analysis of total and allele-specific read counts improves power. | Nature Genetics

Supplementary Figure 2: Joint analysis of total and allele-specific read counts improves power.

From: Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

Supplementary Figure 2

For this study, we developed a likelihood-based method to jointly analyze both total read counts (TReC) and allele-specific read counts (ASReC) from inbred and F1 mice. (a) A negative binomial distribution was generated for TReC, and a beta-binomial distribution was used for ASReC. (b) Simulation and real data support the increased power of this joint model (simulation and real data analyses use the same sample size: 24 = 6(AA) + 6(BB) + 6(AB) + 6(BA).

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