Supplementary Figure 2: The blood vessel and cardiovascular system networks show the best correspondence with the experiment, over and above the tissue-naive network and the bulk of other unrelated tissue networks.
From: Understanding multicellular function and disease with human tissue-specific networks

For each network, genes were ranked on the basis of their connectivity to IL-1β in that network. Then, at each rank, the precision of the predictions up to that rank was calculated as the fraction of genes that are differentially expressed in the experiment. Plotted in each of the three graphs is the precision (y axis) at incremental sets of top-ranked genes (1–100; x axis). The precision for the blood vessel and tissue-naive networks is plotted in solid blue and dashed dark gray, respectively. The median precision at each rank for the cardiovascular system of tissues and all tissues are plotted in dotted blue and gray, respectively. Further, the gray band around the all_tissues median represents the interquartile range of precision values at each rank calculated across all tissues. The three plots correspond to different choices of differentially expressed genes (DEGs) from the microarray, with (a) 500 genes, (b) 250 genes and (c) 1,000 genes. The results in the main text are based on choosing genes from (a) at rank 20.