Supplementary Figure 1: Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis (Msmeg) contain two ɛ (dnaQ) exonuclease homologs. | Nature Genetics

Supplementary Figure 1: Mycobacterium tuberculosis (Mtb) and Mycobacterium smegmatis (Msmeg) contain two ɛ (dnaQ) exonuclease homologs.

From: DNA replication fidelity in Mycobacterium tuberculosis is mediated by an ancestral prokaryotic proofreader

Supplementary Figure 1

(a) Sequence alignment of the ɛ-exonuclease homologs from four different species. Conserved catalytic residues of E. coli ɛ are indicated by blue triangles below the sequences. The clamp-binding motif of E. coli ɛ is boxed in green. (b) Active site of the E. coli ɛ exonuclease. (c) Computational model of the active site of Mtb Rv3711c. (d) Computational model of the active site of Mtb Rv2191.

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