Supplementary Figure 5: Interactions across genomic features.

(a) Proportions of CD34⁺ interactions with an adjacent promoter and of those intervened by other promoters. (b) Examples of distal fragments (black) that interact with an active (green) or inactive (red) promoter in CD34⁺ cells, bridging across other genes. RNA-seq track indicates the gene activity. (c) Examples of promoter-other interactions near CTCF sites in GM12878 cells. Interactions originating data from an inactive KCNJ3 and active DOCK10 promoter bridge over CTCF sites (in red). (d) The proportion of CD34⁺ interactions between a baited fragment and a non-baited fragment that bridge CTCF sites. (e) The directionality of CD34⁺ interactions with respect to TAD boundary positions between baited promoter and non-baited fragments (brown) and between two baited promoters (green). (f) The interactions in GM12878 cells originating from an inactive ACB5 or active ZNF292 promoter are mainly directed away from the nearest TAD boundary. Green bars represent TADs, and vertical arrows highlight the boundaries.