Supplementary Figure 6: Association of interactions with functional annotations.
From: Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
(a) Percentage of fragments across the genome (black) and in promoter interacting fragments (yellow) that encompass a ChromHMM-annotated enhancer. (b) Relative enrichments of interacting fragments for histone modifications in CD34+ cells. Top, relative enrichments of interacting and non-interacting fragments. Below, segregation of interacting fragments into expression quartiles based upon the activity of the associated promoter. (c) Relative enrichments of interacting fragments for chromatin segments in CD34+ cells (left) and the emission parameters defining each state (right). (d) Relative enrichments of non-baited interacting fragments that do not contain canonical enhancers, in GM12878 (left) and CD34+ (right) samples. The enrichment of transcription-associated histone marks in fragments interacting with highly expressed promoters seen for all fragments is also observed in this subset. (e) Relative enrichments for histone modifications for CD34+ interactions between two baited promoters. (f) Relative enrichment of histone modifications for fragments that interact with H3K9me3- or H3K27me3-bound promoters.
