Supplementary Figure 1: Association of paternal age of de novo mutation location with epigenetic variables.
From: Genome-wide patterns and properties of de novo mutations in humans
Using a linear regression model, we tested the association of seven epigenetic variables (DNA replication timing, expression levels, recombination rates, and the H3K27ac, H3K4me1 and H3K4me3 histone modifications), while correcting for GC content, CpG status and sequence coverage. Here we plot the significance of the associations we found with the different epigenetic variables along with the significance threshold level after Bonferroni correction for the six tests we performed (gray dashed line).
