Supplementary Figure 2: Separation of replication timing profiles between the offspring of younger and older fathers.
From: Genome-wide patterns and properties of de novo mutations in humans
We separated our de novo mutation data in two groups based on paternal age. To select a threshold that maximizes the difference in the groups, we considered every integer age in our study as a possible threshold and applied a Kolmogorov-Smirnoff test to compare the distribution of replication timing of de novo mutations between the groups. This plot shows the P values obtained for each of the 27 tests as well as the significance threshold after Bonferroni correction (gray dashed line).
