Supplementary Figure 3: Paternal age effect on de novo mutation replication timing measured in six cell types. | Nature Genetics

Supplementary Figure 3: Paternal age effect on de novo mutation replication timing measured in six cell types.

From: Genome-wide patterns and properties of de novo mutations in humans

Supplementary Figure 3

The distribution of replication timing around de novo mutations in the offspring of younger fathers (orange curves; <28 years old), older fathers (blue curves; ≥28 years old) and simulations (gray areas; 200 simulation sets of 11,020 mutations) in 3 cell types from 4 cell lines41: embryonic stem cells (BG01 ESC, H7 ESC), induced pluripotent stem cells (iPS4) and neural precursor cells (BG01 NPC).

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