Supplementary Figure 4: Paternal and maternal age effect estimates on replication timing based on de novo mutations with known parental origin.
From: Genome-wide patterns and properties of de novo mutations in humans
All effect estimates were computed using a linear regression model. The red line represents the effect estimate from the 630 maternal mutations. The black curve shows the effect estimate for 10,000 samplings of 630 paternal mutations out of the 1,991 available. The effect estimate is significantly larger for paternal mutations (P = 0.0019) when considering the same number of mutations.
