Supplementary Figure 11: Regional plot and conditional analysis at the reported PSCA locus at 8q24 that replicates in Iceland.
From: Loss-of-function variants in ATM confer risk of gastric cancer
Vertical dashed lines indicate the most significant variant at the locus, rs2920295[G] (P = 1.0 × 10−7, OR = 1.21), and the previously reported 5′ UTR variant rs2294008[T] in PSCA that associates with gastric cancer in Iceland (P = 2.4 × 10−7, OR = 1.21). The horizontal dashed line shows the P-value threshold for the locus. Black circles correspond to unadjusted P values; red crosses correspond to P values adjusted for rs2920295. The associations are based on 2,500 gastric cancer patients and 205,652 controls (GC all).
