Supplementary Figure 2: Principal-components analysis (PCA) for inferring ethnicity of 41 unrelated UTMB children whose DNA samples were submitted for genome-wide genotyping.
From: Rare A2ML1 variants confer susceptibility to otitis media
Genotypes were compared to HapMap 3 genotypes (legend as in Supplementary Figure 1). Blue crossed circles denote UTMB children. The three otitis-prone children who carry the variant are indicated by their IDs. For these three children, self-reported ethnicity concurs with the PCA results. Of 38 non-otitis-prone children, 28 (73.7%) were confirmed to be European or Hispanic American, whereas 10 (26.3%) children were African American both by self-reporting and PCA. This ethnic distribution based on the availability of genome-wide genotypes is similar to that based on self-reported ethnicity for either the otitis-prone or non-otitis-prone group of UTMB children, i.e., 68% European or Hispanic American, 31% African American and 1% Asian American.
