Supplementary Figure 3: Molecular modeling for the A2ML1 variants identified in the UTMB otitis-prone children.
From: Rare A2ML1 variants confer susceptibility to otitis media
(a) Stop-gain variants result in loss of thiol-ester and receptor-binding domains. (b) Variants p.Pro356Arg and p.Arg1001Trp are predicted to cause torsional changes and loss of hydrogen bonds. No obvious differences are due to p.Ala810Thr and p.Ala1431Val.
