Supplementary Figure 3: Principal-component analysis of mutational context. | Nature Genetics

Supplementary Figure 3: Principal-component analysis of mutational context.

From: Whole-genome sequencing provides new insights into the clonal architecture of Barrett's esophagus and esophageal adenocarcinoma

Supplementary Figure 3

The counts of each different mutational context in each of the three sets of SNVs (common, Barrett's esophagus (BE) unique, EAC unique) were used as input for a principal-component analysis. There is some separation between the common SNVs and the unique SNVs in the second component, but the differences between the groups are not striking (6.9% variance in the second component). (b) Plot showing the weights of the 96 different mutational contexts. Four mutational contexts—C(A>C)C, G(C>G)G and C(A>T)C (all at the top right-hand side of the plot) as well as T(C>G)A (bottom right)—seem to be the main cause for the separation in the second component.

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