Supplementary Figure 2: GWAS of anthracycline-induced cardiotoxicity in childhood cancer. | Nature Genetics

Supplementary Figure 2: GWAS of anthracycline-induced cardiotoxicity in childhood cancer.

From: A coding variant in RARG confers susceptibility to anthracycline-induced cardiotoxicity in childhood cancer

Supplementary Figure 2

(a) Manhattan plot showing the observed distribution of –log10 (P values) against SNP chromosomal localization (GRCH37.p13). P values are for logistic regression analysis (additive model) with adjustment for age, cumulative dose, tumor type (ALL, Ewing’s sarcoma or rhabdomyosarcoma) and radiotherapy. Red line, P = 1.0 × 10–5 (ref.1). (b) Quantile-quantile plot. Quantile-quantile plot showing the distributions of observed –log10 (P values) plotted against expected –log10 (P values) (λGC = 1.021). Smaller P values than would be expected by chance were observed at the tail of the plot. λGC = 1.021 indicates no obvious population stratification.

Back to article page