Supplementary Figure 10: MMP21 ORF degradation in cetartiodactyla.
From: MMP21 is mutated in human heterotaxy and is required for normal left-right asymmetry in vertebrates
(a,b) The MMP21 ORFs of selected vertebrates are aligned with regions of exon 6 (a) and exon 7 (b) of human MMP21, via the Multiz Alignments track at the UCSC Genome Browser (hg19). MMP21 sequences from all nine available cetartiodactyl genomes are depicted in each panel, plus a selection of other vertebrates. For the first five exons of MMP21, not all nine cetartiodactyl sequences are alignable in Multiz (Supplementary Fig. 9). The regions depicted in exons 6 and 7 show examples of ORF degradation in all nine cetartiodactyls; stops (asterisks), insertions and deletions.
