Supplementary Figure 1: Comparison with the published yeast data.
(a,b) The frequencies of nucleotides near deamination sites are graphed for (a) A3A or (b) A3B expressed in yeast by Taylor et al. in ref.31 (upper panels) and by our group (lower panels). Deaminated cytosines are aligned at 0 on the horizontal axis, flanked by five bases 5′ (–5 to −1) and 3′ (+1 to +5). (c–h) pLogos were generated for C-to-T substitutions from Taylor et al., fixed for C at position 0 (c,d), for TC (e,f) and for TCA (g,h). Note the similarities to the pLogos in Figure 1a–f. (i) Clusters from this study’s yeast data have significantly more mutations per cluster than those from Taylor et al. (j) The A3A clusters from this study span a greater number of bases than the clusters from Taylor et al. Means with 95% confidence intervals and Kolmogorov-Smirnov P values are included in i and j.
