Supplementary Figure 3: Correlation between log of mRNA abundance for A3A or A3B and log of minimal estimate + 1 of TCA mutations induced by APOBEC. | Nature Genetics

Supplementary Figure 3: Correlation between log of mRNA abundance for A3A or A3B and log of minimal estimate + 1 of TCA mutations induced by APOBEC.

From: An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

Supplementary Figure 3

Spearman correlation (ρ) and corresponding P values are computed and shown on log-log plots for (a) all five high-TCA cancer cohorts combined and (b) bladder, (c) breast, (d) head and neck, (e) lung adenocarcinoma and (f) lung squamous cell. Unfilled symbols denote samples not significantly enriched for TCA. Samples with significant TCA enrichment are binned by quartiles. Adding 1 (an arbitrary constant) is necessary to visualize samples with a TCA mutation minimal estimate of 0 on a log scale. In a, c and e, A3A and A3B mRNA abundances both are correlated with mutation load. In b and f, neither is correlated. Only in d is there a distinction, where A3A abundance is correlated, while A3B abundance is not.

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