Supplementary Figure 6: Pitpnb expression in mouse developing heart.
From: Genetic association analyses highlight biological pathways underlying mitral valve prolapse
Cardiac expression of Pitpnb (red) was analyzed at embryonic (E13.5), fetal (E17.5) and adult time points. Pitpnb was detected in valve endothelial and interstitial cells within the mitral leaflets at each of the time points investigated. Expression was also observed in the epicardium (arrow head) and coronary endothelium (arrow) at E17.5. AL, PL, IVS, LV = anterior and posterior mitral leaflets, interventricular septum, and left ventricle, respectively. Green = MF20 (sarcomeric myosin-myocytes), Blue = Hoescht (nuclei).
