Supplementary Figure 2: Igfbp5 expression in mouse developing heart.
From: Genetic association analyses highlight biological pathways underlying mitral valve prolapse
Cardiac expression of Igfbp5 (red) was analyzed at embryonic (E13.5), fetal (E17.5) and adult time points. At the time points investigated, very little Igfbp5 protein was detected in the valves. Expression was observed in the myocardium of the left and right atria and the primary atrial septum (PAS) at E13.5 and E17.5 (arrows) as well as the coronary endothelium in the adult (arrow heads). AL, PL, IVS, LV = anterior and posterior mitral leaflets, interventricular septum, and left ventricle, respectively. Green = MF20 (sarcomeric myosin-myocytes), Blue = Hoescht (nuclei).
