Supplementary Figure 2: Comparison of cumulative allele frequencies for loss-of-function and functional variants in DDD versus ExAC. | Nature Genetics

Supplementary Figure 2: Comparison of cumulative allele frequencies for loss-of-function and functional variants in DDD versus ExAC.

From: Discovery of four recessive developmental disorders using probabilistic genotype and phenotype matching among 4,125 families

Supplementary Figure 2

The cumulative allele frequencies per gene obtained from unaffected DDD parents of European ancestry are on the x axis (log scaled), and the cumulative allele frequencies from the NFE subset of the ExAC data set are on the y axis (log scaled). The dashed line identifies equivalence for DDD and ExAC derived cumulative allele frequencies.

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