Supplementary Figure 12: Comparison of summary statistics for association signals achieving locus-wide significance from the GCTA-COJO joint regression model using genotype data from two reference studies to approximate LD between variants across each fine-mapping region. | Nature Genetics

Supplementary Figure 12: Comparison of summary statistics for association signals achieving locus-wide significance from the GCTA-COJO joint regression model using genotype data from two reference studies to approximate LD between variants across each fine-mapping region.

From: Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci

Supplementary Figure 12

Association summary statistics are based on the meta-analysis of Metabochip studies in 27,206 cases and 57,574 controls of European ancestry. Association summary statistics were obtained using (i) 3,298 T2D cases and 3,708 controls of UK ancestry from GoDARTS (represented on the x axis) and (ii) 4,435 T2D cases and 5,757 controls of Scandinavian ancestry from FUSION (represented on the y axis). Left, comparison of P values (PJ) from the GCTA-COJO joint regression model. Right, comparison of allelic log(OR) (blue diamond) and standard error (gray error bars) from the GCTA-COJO joint regression model.

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