Supplementary Figure 4: Signal plots for association signals at the CDKN2A-CDKN2B locus.

Association summary statistics are based on the meta-analysis of Metabochip studies in 27,206 cases and 57,574 controls of European ancestry. (a) Unconditional. (b) After approximate conditioning on the two index SNPs, rs10811660 and rs10757283. Each point represents a SNP passing quality control in the meta-analysis, plotted with its conditional P value (on a –log₁₀ scale) as a function of genomic position (NCBI Build 37). In each plot, the index variant is represented by the purple symbol. The color coding of all other SNPs indicates LD with the index variant in European-ancestry haplotypes from the 1000 Genomes Project reference panel: red, r² ≥ 0.8; gold, 0.6 ≤ r² < 0.8; green, 0.4 ≤ r² < 0.6; cyan, 0.2 ≤ r² < 0.4; blue, r² < 0.2; gray, r² unknown. Recombination rates are estimated from HapMap Phase 2, and gene annotations are taken from the UCSC Genome Browser.